Pathogenic review: Damn, it feels good to be a virus
Ars Technica · LC · trust 52/100
cyclospora simulator 2026 Pathogenic review: Damn, it feels good to be a virus The hot new roguelite twin-stick shooter lives up to the hype.
27 In Pathogenic , you are the disease. Credit: Aberrant Labs/Slug Disco In Pathogenic , you are the disease. Credit: Aberrant Labs/Slug Disco Text settings Story text Size Small Standard Large Width * Standard Wide Links Standard Orange * Subscribers only Learn more Minimize to nav Over the past couple of weeks, my immune system has been struggling to fight off a cold. It’s been unpleasant, as all colds are. But over the same period—in defiance of my plight—I’ve been waging my own war against immune systems, thanks to Pathogenic , a new roguelite twin-stick shooter from developer Aberrant Labs.
As I’ve downed endless shots of ineffective cough syrup, I’ve done little else with my free time than repeatedly take on the role of a bodily invader. And let me tell you: Being on the enemy’s side is much more fun. Really fun, as it turns out.
Action roguelites are a dime a dozen these days, and it takes something special to stand out. So as quiet Internet whispers turned into widespread cacophonous praise—the little indie game quickly racked up 100,000 sales and an “overwhelmingly positive” review score on Steam—I set aside my default skepticism and gave it a shot.
Developer: Aberrant Labs Publisher: Slug Disco Platform: PC, macOS (Steam) Release Date: July 16, 2026 Price: $10 Links: Steam | Official website
A brief introductory video sets the scene: A hapless lab assistant drops a vial, and wouldn’t you know it, the poor guy has a cut on his ankle. That’s where you come in. As a lone pathogen, you work your way through his body, starting in the skin and then moving on to the intestines, liver, stomach, lungs, and finally heart. Each zone culminates in a boss fight, and you’re continually upgrading your build along the way to keep pace with the stages’ increasing difficulty. Defeat the dreaded heart to kill your host and claim victory (or forge on to the secret brain boss for extra bragging rights).
What this means in gameplay terms is twin-stick shooting through a series of rooms filled with pesky macrophages and T cells, or even rival pathogens (don’t steal my kill!). Combat is fast and frequently demanding; you strafe and dodge around bullet-hell projectiles and hazards with the left stick while trying to keep your weapons trained on enemies with the right.
The setup is very Binding of Isaac— for this author’s money, one of the best video games of all time. In addition to combat rooms, each procedurally generated zone contains a few safe spaces that offer various powerups, either free or purchasable with in-game currency, and you’ll want to scour the level for these and other goodies before taking on the zone’s boss.
Here’s where the game gets interesting. Your little parasite houses various slots to plug in your powerups, and each upgrade affects any weapons (or other upgrades) to which it’s attached. You can freely swap upgrades in and out as you get new ones. Add effects like fire or electric damage to your attacks, slot in new projectile or melee weapons, or even pick up active abilities to fill out your kit. Some upgrades allow you to “overcharge” and give bonuses to other nodes in your system when certain requirements are met. The game definitely has more than a little cell-stage Spore in it.
The magic is in how all these upgrades interact. The Binding of Isaac is known for its many and varied “synergies”—items that, when combined, produce surprising and delightful effects. That’s what Pathogenic is all about: creating game-breaking, frame-rate-hobbling builds that let you bully the game’s enemies into submission. Here, though, those synergies are modular and customizable.
Say you’re using a weapon that spits out mines. Cool, but basic. But then you attach an upgrade that makes those mines grow in size and power over time. And then you add an effect that causes electricity to chain between them. Not content, you buff the damage of the electricity or infuse some other effect into it. Then, just for good measure, you make the whole thing home in on enemies.
There are an impressive number of interactions, and the game revels in piquing your curiosity. So many times, when connecting items, I’ve thought, “Surely this won’t work—OH MY GOD, IT DOES.”
The most satisfying part of roguelites isn’t becoming powerful because the numbers went up; it’s becoming powerful due to your own cleverness. Pathogenic is a toybox that rewards experimentation.
Get so strong, you can barely see what you’re doing. Aberrant Labs/Slug Disco Pretty! Aberrant Labs/Slug Disco Pretty! Aberrant Labs/Slug Disco Get so strong, you can barely see what you’re doing. Aberrant Labs/Slug Disco Pretty! Aberrant Labs/Slug Disco Enemies drop DNA helixes on death; collect them to level up and mutate—i.e., choose between four random passive effects. Every few levels, you’ll be able to evolve into a newly configured pathogen with more slots for upgrades. Different pathogens offer different ways to build your character, including one that starts with very limited slots but lets you add them exactly where you want over time.
Between runs, you’ll spend the game’s meta-currency (mostly obtained from bosses) to unlock permanent upgrades on a skill tree, making subsequent runs a bit smoother. Each pathogen has its own tree; I’ve been focusing mostly on one for now since progression is slow but steady. There’s a ton to unlock, and completionists should be kept busy for quite some time.
All the game’s content is rich in theme—the items have scientific-sounding names, and the stages pose thematically appropriate hazards. In the lungs, for instance, wind pushes you around, and the intestine stage features a long, winding hallway. The visuals are excellent, the music rocks, and the sound design is punchy.
You and your enemies have what the developer calls “soft body physics,” meaning…
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